Top Critical Care Trials of 2015

Jack Iwashyna, Aidan Burrell, Andrew Udy and I are presenting a quick-fire tour of the ‘Top Critical Care Trials of 2015’ at The Alfred ICU Journal Club tomorrow.

Here are the Pubmed links for the articles that made the cut (in alphabetical order):

  • Amato MB, Meade MO, Slutsky AS. Driving pressure and survival in the acute respiratory distress syndrome. The New England journal of medicine. 372(8):747-55. 2015. [pubmed] (not really a trial as such…)
  • Andrews PJ, Sinclair HL, Rodriguez A. Hypothermia for Intracranial Hypertension after Traumatic Brain Injury (Eurotherm3236). The New England journal of medicine. 2015. [pubmed]
  • Holcomb JB, Tilley BC, Baraniuk S. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 313(5):471-82. 2015. [pubmed]
  • Kaukonen KM, Bailey M, Pilcher D, Cooper DJ, Bellomo R. Systemic inflammatory response syndrome criteria in defining severe sepsis. The New England journal of medicine. 372(17):1629-38. 2015. [pubmed] (also not really a trial… but hey!)
  • Lacroix J, Hébert PC, Fergusson DA. Age of transfused blood in critically ill adults (ABLE). The New England journal of medicine. 372(15):1410-8. 2015. [pubmed]
  • Mouncey PR, Osborn TM, Power GS. Trial of early, goal-directed resuscitation for septic shock (PROMISE). The New England journal of medicine. 372(14):1301-11. 2015. [pubmed]
  • Nichol A, French C, Little L. Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial. Lancet (London, England). 2015. [pubmed]
  • Sawyer RG, Claridge JA, Nathens AB. Trial of short-course antimicrobial therapy for intraabdominal infection (STOP-IT). The New England journal of medicine. 372(21):1996-2005. 2015. [pubmed]
  • Young P, Bailey M, Beasley R. Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit: The SPLIT Randomized Clinical Trial. JAMA. 314(16):1701-10. 2015. [pubmed]
  • Young P, Saxena M, Bellomo R. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection (HEAT). The New England journal of medicine. 373(23):2215-24. 2015. [pubmed]

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